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	Provedor de dados BJMBR (2) Autor Chen,Y. (1) Cheng,Chang (1) Dong-Feng,Zeng (1) Li,X. (1) Liu,A. (1) Pei-Yan,Kong (1) Shang,G. (1) Ting,Liu (1) Wang,L. (1) Xi,Zhang (1) Xing-Hua,Chen (1) Xue,Liang (1) Zhang,C. (1) Zhang,H. (1) Zhao,Z. (1) Mais... Palavra-chave HIF-1α (2) Angiogenesis (1) Hepatopulmonary syndrome (1) Human bone marrow stromal cells (hBMSCs) (1) Leukemia (1) Quercetin (1) RNAi (1) SDF-1α (1) VEGF (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2016 (1) 2012 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Quercetin alleviates pulmonary angiogenesis in a rat model of hepatopulmonary syndrome BJMBR Li,X.; Chen,Y.; Wang,L.; Shang,G.; Zhang,C.; Zhao,Z.; Zhang,H.; Liu,A.. Quercetin shows protective effects against hepatopulmonary syndrome (HPS), as demonstrated in a rat model. However, whether these effects involve pulmonary vascular angiogenesis in HPS remains unclear. Therefore, this study aimed to assess the effect of quercetin on pulmonary vascular angiogenesis and explore the underlying mechanisms. Male Sprague-Dawley rats weighing 200-250 g underwent sham operation or common bile duct ligation (CBDL). Two weeks after surgery, HIF-1α and NFκB levels were assessed in rat lung tissue by immunohistochemistry and western blot. Then, CBDL and sham-operated rats were further divided into 2 subgroups each to receive intraperitoneal administration of quercetin (50 mg/kg daily) or 0.2% Tween for two weeks: Sham (Sham+Tween;... Tipo: Info:eu-repo/semantics/article Palavras-chave: Angiogenesis; Hepatopulmonary syndrome; HIF-1α; Quercetin. Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000700606 Silencing HIF-1α reduces the adhesion and secretion functions of acute leukemia hBMSCs BJMBR Dong-Feng,Zeng; Ting,Liu; Cheng,Chang; Xi,Zhang; Xue,Liang; Xing-Hua,Chen; Pei-Yan,Kong. Hypoxia inducible factor-1α (HIF-1α) is an important transcription factor, which plays a critical role in the formation of solid tumor and its microenviroment. The objective of the present study was to evaluate the expression and function of HIF-1α in human leukemia bone marrow stromal cells (BMSCs) and to identify the downstream targets of HIF-1α. HIF-1α expression was detected at both the RNA and protein levels using real-time PCR and immunohistochemistry, respectively. Vascular endothelial growth factor (VEGF) and stromal cell-derived factor-1α (SDF-1α) were detected in stromal cells by enzyme-linked immunosorbent assay. HIF-1α was blocked by constructing the lentiviral RNAi vector system and infecting the BMSCs. The Jurkat cell/BMSC co-cultured system... Tipo: Info:eu-repo/semantics/article Palavras-chave: HIF-1α; Human bone marrow stromal cells (hBMSCs); Leukemia; RNAi; SDF-1α; VEGF. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012001000004 Registros recuperados: 2 Primeira ... 1 ... Última

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